Experiences with procaine hydrochloride

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Colorimetric determination of procaine hydrochloride in pharmaceutical preparations.

A new rapid, specific, and convenient colorimetric method for the determination of procaine hydrochloride in pharmaceutical preparations is described. This method is based on measurement of the intensity of the orange-red color developed when procaine hydrochloride is allowed to react with 1,2-naphthoquinone-4-sulfonic acid sodium salt in aqueous solution. Beer's law is followed over 6.0--20.0 ...

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388 Procaine Amide Hydrochloride in Supraventricular Arrhythmias Table 1

The effect of the intravenous administration of procaine amide in 25 patients with supraventricular arrhythmias is reported. The data, including six conversions of auricular fibrillation, indicate a pronounced effect of this drug on the auricles as well as on the heart as a whole. Special attention is directed to the finding of frequent and undesirable electrocardiographic and hypotensive effec...

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Induction of alkaline phosphatase in Escherichia coli: effect of procaine hydrochloride.

The effect of procaine hydrochloride, an anesthetic known to alter membrane structure, on the induced formation of alkaline phosphatase, a periplasmic enzyme, in Escherichia coli was investigated. Procaine hydrochloride specifically arrested the appearance of active alkaline phosphatase while permitting the induction of another enzyme, beta-galactosidase, which is internally localized. Evidence...

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A study of the effect of procaine amide hydrochloride in supraventricular arrhythmias.

The effect of the intravenous administration of procaine amide in 25 patients with supraventricular arrhythmias is reported. The data, including six conversions of auricular fibrillation, indicate a pronounced effect of this drug on the auricles as well as on the heart as a whole. Special attention is directed to the finding of frequent and undesirable electrocardiographic and hypotensive effec...

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Plasma concentration and local anesthetic activity of procaine hydrochloride following subcutaneous administration to horses.

OBJECTIVE To determine the durations of the local anesthetic effect and plasma procaine concentrations associated with 5- and 10-mg doses of procaine hydrochloride (with or without 100 microg of epinephrine) administered SC over the lateral palmar digital nerves of horses. ANIMALS 6 healthy adult horses. PROCEDURES The hoof withdrawal reflex latency (HWRL) period was determined by use of a ...

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ژورنال

عنوان ژورنال: Canadian Anaesthetists’ Society Journal

سال: 1957

ISSN: 0008-2856,1496-8975

DOI: 10.1007/bf03009198